Table 2. Identification of cell apoptosis and necrosis

Cell groups	Cell percentage (%)
	Negative control	RA@SiNPs	RA
Early apoptotic cells	0.05±0.07	10.50±2.83	7.60±1.13
Late apoptotic cells	0.00±0.00	32.50±2.40	27.40±3.11
Survival cells	99.65±0.21	50.10±5.37	64.45±4.46
Necrotic cells	0.30±0.28	6.90±0.14	0.55±0.21

AGS cells were incubated with 140 μg/mL of RA or RA@SiNPs for 24 hours. Untreated cells were the negative control. Each group was performed in two wells. Cells were stained with an Annexin V-FITC/propidium iodide kit and detected by a flow cytometry system. Data were expressed as mean±SD of three independent experiments. All p-values were more than 0.05.
RA, rosmarinic acid; AGS, gastric adenocarcinoma; FITC, fluorescein isothiocyanate.