Table 1. Cell survival in toxicity assay

Concentration of SiNPs/RA (μg/mL)	CVR (%)
	Negative control	SiNPs	RA@SiNPs	RA	PTX
0	100.00	NA	NA	NA	NA
30/17.5	NA	99.76±4.40	98.21±7.39	89.38±9.05	NA
60/35	NA	97.67±5.04	98.44±1.75	83.90±4.25	NA
120/70	NA	91.75±6.00	77.53±2.91	53.76±1.25	NA
240/140	NA	86.65±1.81	54.31±9.16	43.60±7.80	NA
2	NA	NA	NA	NA	70.32±3.09
20	NA	NA	NA	NA	49.70±5.23

AGS cells were incubated with different doses of RA@SiNPs, SiNPs, RA, and PTX, or without reagent (0 μg/mL, considered as negative control) for 24 hours. Each sample was tested on three wells. After 48 hours of additional culture in fresh medium, the cytotoxic was assessed by the CCK-8. The OD measurement was performed at 450 nm and converted into the cell viability ratio. Data were expressed as mean±SD of three independent experiments. All p-values were more than 0.05. CVR, cell viability ratio; RA, rosmarinic acid; PTX, paclitaxel; AGS, adenocarcinoma; CCK-8, Cell Counting Kit-8; OD, optical density, NA, not applicable.