Table 3. Univariable and multivariable Cox proportional hazards model analysis of thrombocytopenia

Variable	Univariable analysis			Multivariable analysis
	HR	95% CI	p-value	aHR	95% CI	p-value
Renal impairment1)	2.693	1.58–4.59	<0.001	2.278	1.328–3.907	0.0028
Age	1.02	1.002–1.038	0.031	NA
Female	0.905	0.530–1.546	0.716	NA
Height	0.999	0.960–1.039	0.96	NA
Weight	0.991	0.971–1.012	0.391	NA
Charlson comorbidity index	1.131	0.996–1.283	0.057	NA
Low baseline platelet2)	0.596	0.143–2.482	0.477	NA
High baseline total bilirubin3)	3.509	1.471–8.372	0.005	NA
Linezolid dose4)	1.056	0.944–1.182	0.34	NA
Duration of linezolid therapy	0.966	0.941–0.991	0.009	0.972	0.946–0.999	0.0396

Estimated glomerular filtration rate using Chronic Kidney Disease Epidemiology Collaboration equation (eGFR CKD-EPI)<60 mL/min per 1.73 m².
Platelet count, <150×10³ cells/μL.
Total bilirubin, ≥20.5 umol/L.
Dose per kg per day.
aHR, adjusted hazard ratio; CI, confidence interval; eGFR, estimated glomerular filtration rate; CKD-EPI, chronic kidney disease epidemiology collaboration; NA, not applicable