Table 2. Current and potential future clinical indications for biphasic in-vitro maturation

Indication	Current usage	Level of expertise of ART center/clinician
PCOS	Common	Beginner
High AFC	Common	Beginner
Normal AFC	Uncommon	Intermediate
Low AFC	Rare	Advanced
Gonadotrophin-resistant ovary syndrome	Rare	Advanced
Ovarian auto-immunity	Rare	Advanced
Onco-fertility - from OTO	Rare	Advanced
Onco-fertility - from OPU	Rare	Advanced
Tourism-fertility treatment	Uncommon	Intermediate
Social egg freezing	Common	Intermediate

ART, assisted reproductive technology; PCOS, polycystic ovary syndrome; AFC, antral follicle count; OTO, oocyte-tissue oocyte; OPU, oocyte pick-up.